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<i>Alstonia rostrata<_i> C. E. C. Fischer

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) CFTR (1) Lipoxygenase (1) Monoamine Oxidase (1)
By Research Areas:	Cancer (5) Infection (2) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2074

Picrinine	Lipoxygenase	Inflammation/Immunology
Picrinine, an akuammiline alkaloid, is isolated from the leaves of Alstonia scholaris. Picrinine exhibits anti-inflammatory activity through inhibition of the 5-lipoxygenase enzyme .

HY-N3210

Nb-Demethylechitamine	Others	Cancer
Nb-Demethylechitamine is an alkaloid isolated from the methanol extract of Alstonia rostrata twigs. Nb-Demethylechitamine has in vitro cytotoxic activity against several human cancer cell lines, including human myeloid leukemia HL-60, liver cancer SMMC-7721, lung cancer A-549, breast cancer MCF-7, and colon cancer SW480 cells .

HY-N10376

Lagunamine

19-Hydroxytubotaiwine
Others Infection Cancer

Lagunamine (19-Hydroxytubotaiwine) is an alkaloid that isolated from the leaves of Philippine Alstonia scholaris. .

Lagunamine 19-Hydroxytubotaiwine	Others	Infection Cancer
Lagunamine (19-Hydroxytubotaiwine) is an alkaloid that isolated from the leaves of Philippine Alstonia scholaris. .

HY-N8315

Echitovenidine	Monoamine Oxidase	Neurological Disease
Echitovenidine is an alkaloid that can be isolated from Alstonia yunnanensis. Echitovenidine is an inhibitor of monoamine oxidase (MAO) .

HY-N3217

N1-Methoxymethyl picrinine

Others Others

N1-Methoxymethyl picrinine (compound 3) is an indole alkaloid that can be isolated from the leaves of Alstonia scholaris .
HY-N6911

Licorice-saponin H2

(18β,20α)-Glycyrrhizic acid
Others Metabolic Disease

Licorice-saponin H2 ((18β,20α)-Glycyrrhizic acid) is a saponin from Glycyrrhiza uralensis Fischer .
HY-N4002

Isoboonein

Others Others

Isoboonein (compound 5) is a natural product that can be found in Alstonia scholaris .
HY-N3374

Lochnerine

10-O-Methylsarpagine
Others Others

Lochnerine is an indole alkaloid can be isolated from the stem bark extract of Alstonia macrophylla .
HY-N12244

Echitaminic acid

Others Others

Echitaminic acid (compound 3) is an alkaloid isolated from the trunk bark of Alstonia sellers collected in Timor, Indonesia .

N1-Methoxymethyl picrinine	Others	Others
N1-Methoxymethyl picrinine (compound 3) is an indole alkaloid that can be isolated from the leaves of Alstonia scholaris .

Licorice-saponin H2 (18β,20α)-Glycyrrhizic acid	Others	Metabolic Disease
Licorice-saponin H2 ((18β,20α)-Glycyrrhizic acid) is a saponin from Glycyrrhiza uralensis Fischer .

Isoboonein	Others	Others
Isoboonein (compound 5) is a natural product that can be found in Alstonia scholaris .

Lochnerine 10-O-Methylsarpagine	Others	Others
Lochnerine is an indole alkaloid can be isolated from the stem bark extract of Alstonia macrophylla .

Echitaminic acid	Others	Others
Echitaminic acid (compound 3) is an alkaloid isolated from the trunk bark of Alstonia sellers collected in Timor, Indonesia .

HY-135743

Apovincamine cis-Apovincamine; (+)-Apovincamine	Others	Cancer
Apovincamine (cis-Apovincamine) is an indole alkaloid isolated from the Malaysian Alstonia pneumatophora (Apocynaceae). Apovincamine shows anti-melanogenesis activity .

HY-N9161

Echitoveniline	Others	Cancer
Echitoveniline, a monoterpenoid indole alkaloid, can be isolated from Alstonia mairei. Echitoveniline has no significant cytotoxicity against cancer cells (IC₅₀: > 40 μM) .

HY-N1251

Scholaricine
Scholaricine (compound 13 ) is an alkaloid isolated from the leaf and stem-bark extracts of Alstonia spatulata. Scholaricine reverse multidrug resistance in vincristine-resistant KB cells with an IC₅₀ value of 13.35 μM .

HY-117492

Aconiazide

Isonicophen
Others Infection

Aconiazide (Isonicophen) is a orally active hydrazone derivative of isoniazid, and can be used for study of tuberculosis .

Aconiazide Isonicophen	Others	Infection
Aconiazide (Isonicophen) is a orally active hydrazone derivative of isoniazid, and can be used for study of tuberculosis .

HY-N3797A

Echitamine chloride Ditaine chloride	Apoptosis	Cancer
Echitamine (Ditaine) chloride is the major monoterpene indole alkaloid present in Alstonia scholaris with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits pancreatic lipase with an IC₅₀ of 10.92 μM .

HY-136939

CFTR corrector 6	CFTR	Metabolic Disease Inflammation/Immunology
CFTR corrector 6 is a potent potentiator of Cystic Fibrosis Transmembrane conductance Regulator (CFTR). CFTR corrector 6 has the potential for cystic fibrosis (CF) and other CFTR associated disorders research .

Picrinine	Apocynaceae Alkaloids other families Classification of Application Fields Source classification Alstonia scholaris (L.) R. Br. Plants Inflammation/Immunology Disease Research Fields Indole Alkaloids	Lipoxygenase
Picrinine, an akuammiline alkaloid, is isolated from the leaves of Alstonia scholaris. Picrinine exhibits anti-inflammatory activity through inhibition of the 5-lipoxygenase enzyme .

Nb-Demethylechitamine	Apocynaceae Structural Classification Alkaloids Source classification Plants Indole Alkaloids Alstonia rostrata C. E. C. Fischer	Others
Nb-Demethylechitamine is an alkaloid isolated from the methanol extract of Alstonia rostrata twigs. Nb-Demethylechitamine has in vitro cytotoxic activity against several human cancer cell lines, including human myeloid leukemia HL-60, liver cancer SMMC-7721, lung cancer A-549, breast cancer MCF-7, and colon cancer SW480 cells .

Lagunamine 19-Hydroxytubotaiwine	Apocynaceae Source classification Alstonia scholaris (L.) R. Br. Plants	Others
Lagunamine (19-Hydroxytubotaiwine) is an alkaloid that isolated from the leaves of Philippine Alstonia scholaris. .

Echitovenidine	Apocynaceae Structural Classification Alkaloids Alstonia yunnanensis Diels Source classification Plants	Monoamine Oxidase
Echitovenidine is an alkaloid that can be isolated from Alstonia yunnanensis. Echitovenidine is an inhibitor of monoamine oxidase (MAO) .

N1-Methoxymethyl picrinine	Apocynaceae Structural Classification Alkaloids Source classification Alstonia scholaris (L.) R. Br. Plants Indole Alkaloids	Others
N1-Methoxymethyl picrinine (compound 3) is an indole alkaloid that can be isolated from the leaves of Alstonia scholaris .

Licorice-saponin H2 (18β,20α)-Glycyrrhizic acid	Triterpenes Classification of Application Fields Leguminosae Terpenoids Source classification Metabolic Disease Plants Disease Research Fields Glycyrrhiza uralensis Fisch.	Others
Licorice-saponin H2 ((18β,20α)-Glycyrrhizic acid) is a saponin from Glycyrrhiza uralensis Fischer .

Isoboonein	Apocynaceae Structural Classification Iridoids Terpenoids Source classification Alstonia scholaris (L.) R. Br. Plants	Others
Isoboonein (compound 5) is a natural product that can be found in Alstonia scholaris .

Lochnerine 10-O-Methylsarpagine	Apocynaceae Structural Classification Alkaloids Alstonia macrophylla Wall. ex G. Don Source classification Plants	Others
Lochnerine is an indole alkaloid can be isolated from the stem bark extract of Alstonia macrophylla .

Echitaminic acid	Apocynaceae Structural Classification Alkaloids Source classification Alstonia scholaris (L.) R. Br. Plants Indole Alkaloids	Others
Echitaminic acid (compound 3) is an alkaloid isolated from the trunk bark of Alstonia sellers collected in Timor, Indonesia .

Apovincamine cis-Apovincamine; (+)-Apovincamine	Apocynaceae Alkaloids Structural Classification Alstonia yunnanensis Diels Classification of Application Fields Source classification Plants Disease Research Fields Indole Alkaloids Cancer	Others
Apovincamine (cis-Apovincamine) is an indole alkaloid isolated from the Malaysian Alstonia pneumatophora (Apocynaceae). Apovincamine shows anti-melanogenesis activity .

Echitoveniline	Apocynaceae Structural Classification Alkaloids Other Monoterpenes Terpenoids Source classification Alstonia mairei Lévl. Plants Indole Alkaloids	Others
Echitoveniline, a monoterpenoid indole alkaloid, can be isolated from Alstonia mairei. Echitoveniline has no significant cytotoxicity against cancer cells (IC₅₀: > 40 μM) .

Echitamine chloride Ditaine chloride	Apocynaceae Alkaloids Structural Classification Classification of Application Fields Source classification Alstonia scholaris (L.) R. Br. Plants Disease Research Fields Indole Alkaloids Cancer	Apoptosis
Echitamine (Ditaine) chloride is the major monoterpene indole alkaloid present in Alstonia scholaris with potent anti-tumour activity. Echitamine chloride induces DNA fragmentation and cells apoptosis. Echitamine chloride inhibits pancreatic lipase with an IC₅₀ of 10.92 μM .

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<i>Alstonia rostrata<_i> C. E. C. Fischer

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